Anna Nicole Smith rose to international notoriety after her death in 2007, when her trial made international headlines. The 39-year-old actress and model was found overdosing in her hotel room in Florida, but was unable to be revived. A later toxicology report showed a combination of drugs in her system, primarily the sleeping medication chloral hydrate, alongside the benzodiazepine class drugs diazepam, oxazepam, lorazepam, and clonazepam. She had previously taken methadone, although this was ruled as non-contributing. In addition, Smith’s growth hormone injections may have contributed to her death.
Anna Nicole Smith’s use of prescription medication was illicit and outside of prescription, most likely for recreational or self-medication use. Most of the prescription medications were made out to friends rather than herself and she had taken them in significantly larger quantities than prescribed.